Objective: To study the effects of salvianolic acid B(Sal-B) on blood glucose

lipid

renal function

insulin levels

as well as insulin and glucose tolerance in rat models with type 2 diabetes. Method: The rat type 2 diabetes model was established by feeding with high glucose and fat diets and intraperitoneally injecting with 30 mg·kg-1 STZ. The rats were divided into four groups: normal

model

diamicron (26.7 mg·kg-1)and Sal-B(187 mg·kg-1) group

corresponding drugs were orally administrated for four weeks. At the end of administration

blood samples were collected

and blood glucose

glycosylated hemoglobin(HBA)

triglyceride

total cholesterol

creatinine

blood urea nitrogen

and insulin levels were detected. Then insulin sensitivity index was calculated. Insulin sensitivity of rats was evaluated by insulin and glucose tolerance tests. Result: Sal-B and diamicron not only significantly decreased fasting blood glucose and lipid

insulin and HbA1 c levels(P<0.01)

but also improved renal function

insulin sensitivity

insulin and glucose tolerance

which were remarkably different from the model group(P<0.05

P<0.01). Conclusion: Sal-B can lower blood glucose and lipid levels

protect kidney

ameliorate glucose and lipid disorders

and insulin resistance in rat models with type 2 diabetes.