Objective: To study the rule of the dynamic HPLC fingerprints of safflower from different source and find a comprehensive evaluation method suitable for quality control of TCM(or compounds) multicomponent. Method: Thirty-two batches safflower sample were collected and safflower yellow A was used for reference. RP-HPLC was used to establish chromatographic fingerprints for evaluated and analyzed by total quantum statistical moment similarity (TQSMS) and principal component analysis (PCA). Result: Twenty samples in 32 comply with Chinese pharmacopoeia; the TQSMPM parameters of the AUCT

MCRTT

VCRTT were 4 454 mV · s-1

27.89 min

305.49 min2

and the RSD is 22%

4.69%

7.32% respectively for all. The 20 samples up to standard safflower were analyzed by TQSMS:37 common characteristic peaks

the similarity range of 0.82-0.99 contrasts to the number 5 samples

the average similarity was 0.94

RSD was 5.03%. Seven principal components which accounted for over 88.72% of the total variance were extracted from the original data. Conclusion: TQSMS combined with PCA can comprehensively analyze the quality and dynamic regulation of safflower

and it is an effective method that is fit to the quality evaluation of chemical components group of Chinese medicine.