Objective:To classify traditional Chinese medicines in treatment of the hand foot and mouth disease(HFMD) to provide a new way for the further study on the formula rules and clinical application of these traditional Chinese medicines. Method:The data were collected from January

2000 to December

2010.From more than 126 Chinese herbal compounds which were used to 20 cases effectively and havd 10 or more frequency

40 compounds were chosen. Based on the property of a medicine including the channel tropism and the effect of multiple variables

all the paper were published in the journals. The SPSS 19 software package was used

and the distribution of traditional Chinese medicines were dealt with cluster and correlative analysis

which were based on fuzzy mathematics. Result:Through clustering method

different categories were separated

using the principle of optimization

The data were divided into 4

6 and 8 categories. The cluster analysis showed that 4 categories was better. The four kinds of medicine were belongs to heat clearing

diaphoretic

resolving dampness drug and eliminating dampness through diuresis medicine. Conclusion:The cluster analysis method can be used to classify different classes and havs similar efficacy of traditional Chinese medicines.There is a relation between the treatment of Hand Foot and Mouth Disease and the theory of traditional Chinese medicine

which is significant for the further study on clinical application of these traditional Chinese medicines.