Effect of Fuzheng Jiedu Granula on Urinary Micro-protein and Urinary Enzyme in Rats Exposed to Nickel

TENG Yu-lian; LV Xiao-yun; ZHAO Jian-xiong

您当前的位置：

首页 >

文章列表页 >

Effect of Fuzheng Jiedu Granula on Urinary Micro-protein and Urinary Enzyme in Rats Exposed to Nickel

更新时间：2024-01-04

- Effect of Fuzheng Jiedu Granula on Urinary Micro-protein and Urinary Enzyme in Rats Exposed to Nickel
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 12, Pages: 170-172(2012)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2012
- 稿件说明：
移动端阅览
TENG Yu-lian, LV Xiao-yun, ZHAO Jian-xiong. Effect of Fuzheng Jiedu Granula on Urinary Micro-protein and Urinary Enzyme in Rats Exposed to Nickel[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(12): 170-172.
DOI：

TENG Yu-lian, LV Xiao-yun, ZHAO Jian-xiong. Effect of Fuzheng Jiedu Granula on Urinary Micro-protein and Urinary Enzyme in Rats Exposed to Nickel[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(12): 170-172. DOI：

摘要

目的: 观察扶正解毒颗粒(FJG)对硫酸镍(NiSO4)暴露肾损伤大鼠的保护作用。方法: 50只Wistar大鼠采用NiSO4 2.5 mg·kg-1·d-1 ip(连续7 d

此后间日1次)制备肾损伤模型

随机分为NiSO4组(模型组)、 FJG高、中、低剂量组(20

5 g·kg-1·d-1)、二巯基丁二酸(DMSA

50 mg·kg-1·d-1)组。另设NS组(空白对照)及FJG对照组(FJG 10 g·kg-1·d-1)。各组大鼠ig 1次/d

共4周。分别采用放射免疫法(RIA)、光电比色法及酶法检测尿α1-微球蛋白(α1-MG)、N-乙酰-β-D氨基葡萄糖苷酶(NAG)及尿肌酐(UCr)的变化。结果: NiSO4组尿α1-MG及 NAG活性(NAG/ UCr)较NS组显著增高(P<0.05和P<0.01)

与NiSO4组相比

FJG各组尿α1-MG及 NAG活性则明显降低

尤以FJG高、中剂量组为著(P<0.05和P<0.01)。结论: 尿α1-MG及 NAG活性增高与早期镍性肾损伤存在关联

中药FJG对镍性肾损伤大鼠具有较好的保护作用。

Abstract

Objective: To study the effect of Fuzheng Jiedu granula(FJG) on the renal injury in rats exposed to nickel sulfate(NiSO4). Method: Fifty Wistar rats were made into nephrotoxicity models by intraperitoneal injection of NiSO4 (2.5 mg·kg-1·d-1).They were randomized into 5 groups

model group

high dose of FJG group(20 g·kg-1·d-1)

middle dose of FJG group(10 g·kg-1·d-1)

low dose of FJG group(5 g·kg-1·d-1)

meso-2

3-dimercaptosuccinic acid(DMSA) group(0.05 g·kg-1·d-1). Twenty Wistar rats were divided into NS group and FJG control group(10 g·kg-1·d-1) randomly. The rats in each group were treated with intragastric administration once every day for four weeks. Urinary α1-microglobulin(α1-MG)

urinary N-acetyl-β-D-glucosaminidase(NAG) and urinary creatinine were detected by radioimmunity assay(RIA)

photoelectric colorimetry assay and enzymic assay

respectively. Result: In NiSO4 group

urinary α1-MG and NAG activity(NAG/ UCr) were increased remarkably(P<0.05

P<0.01). Compared with that of NiSO4 group

the indexes montioned above in FJG groups decreased obviously(P<0.05

P<0.01). Conclusion: Urinary α1-MG and NAG activity enhancement could be correlated with nickel-induced nephrotoxicity. FJG could protect rats from the renal injury induced by nickel.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

No data

Related Author

No data

Related Institution

No data

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰