Effect of Different Traditional Chinese Medicine for Nourishing Yin on Lung Chemical Carcinogenesis and Antitumor Immune Function in Mice
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Effect of Different Traditional Chinese Medicine for Nourishing Yin on Lung Chemical Carcinogenesis and Antitumor Immune Function in Mice
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 13, Pages: 226-229(2012)
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Published:2012
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GUO Hui-jun, ZHU Jin-hua, LIU Chun-hua, et al. Effect of Different Traditional Chinese Medicine for Nourishing Yin on Lung Chemical Carcinogenesis and Antitumor Immune Function in Mice[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(13): 226-229.
DOI:
GUO Hui-jun, ZHU Jin-hua, LIU Chun-hua, et al. Effect of Different Traditional Chinese Medicine for Nourishing Yin on Lung Chemical Carcinogenesis and Antitumor Immune Function in Mice[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(13): 226-229.DOI:
Effect of Different Traditional Chinese Medicine for Nourishing Yin on Lung Chemical Carcinogenesis and Antitumor Immune Function in Mice
Objective: The effect of Liuwei Dihuang Wan(LWDH)and Erdong Gao (ED)on the tumorigenesis and the antitumor immune function were studied in a model of chemical carcinogenesis in the mouse lung. Method: Thirty three female Kunming mice with urethane subcutaneous injection(1 g·kg-1·d-1)were randomized into three groups: the control group
the group treated with LWDH(ig
1.56 g·kg-1·d-1)and the group treated with ED(ig
0.78 g·kg-1·d-1). The mice were sacrificed after 100 days to investigate the rate of tumor formation by naked eye
pathological section and hematoxylin-eosin staining.The spleen index
thymus index
activity of macrophage and content of tumor necrosis factor alpha (TNF-α) in the blood serum were tested. Result: In the process of lung carcinogenesis
compared with control group
LWDH and ED could reduce the rate of lung chemical carcinogenesis which was 18.2% and 36.4%
respectively. Compared with control group
LWDH and ED could also increase the spleen index
elevate the activity of macrophage(P<0.05 or P<0.01)and decrease the content of TNF-α in the blood serum(P<0.05 or P<0.01). Conclusion: LWDH and ED can delay the occurrence and development of lung carcinoma induced by urethane through enhancing antitumor immunity and decreasing content of the inflammatory factor.
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Related Author
WANG Xi-jun1
ZHANG Ning1
SUN Hui1
LI Li-jing2
LV Hai-tao1
ZHENG Li-xiang
LIU Hong-yu
QIAO Hong-dan
Related Institution
Jiangxi University of Traditional Chinese Medicine