Enhancing Effect of Volatile Oil from on Percutaneous Penetration of Rotundine Patch
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Enhancing Effect of Volatile Oil from on Percutaneous Penetration of Rotundine Patch
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 13, Pages: 7-10(2012)
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Published:2012
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HUANG Jin-e, MA Yun-shu, ZHANG Gui-hua, et al. Enhancing Effect of Volatile Oil from on Percutaneous Penetration of Rotundine Patch[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(13): 7-10.
DOI:
HUANG Jin-e, MA Yun-shu, ZHANG Gui-hua, et al. Enhancing Effect of Volatile Oil from on Percutaneous Penetration of Rotundine Patch[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(13): 7-10.DOI:
Enhancing Effect of Volatile Oil from on Percutaneous Penetration of Rotundine Patch
Objective: To study on effect of volatile oil from Amomum tsaoko on percutaneous penetration of Rotundine patch. Method: In vitro percutaneous penetration test in rat was conducted by using a modified Franz diffusion cell.Accumulative penetration volume of rotundine was determined by HPLC
enhancing effect of different concentrations of volatile oil from A. tsaoko on percutaneous permeation of rotundine in the patch was investigated. Result: The concentration of 5%
7% and 10% of volatile oil from A. tsaoko had a certain enhancing effect on permeation of rotundine in the patch
average cumulative penetration volume of rotundine in 12 h of 5%
7%
10% volatile oil were 3.848
4.329
4.914 mg·cm-2
multiples of enhancing permeation in 12 hours were 1.014
1.127
1.282. Conclusion: Volatile oil from A. tsaoko could enhance percutaneous penetration of rotundine in the patch.With a certain range
percutaneous penetration was enhancing with increasing the concentration of volatile oil from A. tsaoko.
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