Objective:To investigate the changes in plasma oxidized low-density lipoprotein (ox-LDL)in the patients with coronary heart disease

and to evaluate the clinical value of detection for ox-LDL level.Method: Enzyme-linked immunosorbent assay(ELISA) was used to measure the plasma ox-LDL in 189 patients with coronary heart disease

among them 103 were acute coronary syndrome (ACS) and 86 were non-ACS patients

and in additional 210 healthy controls. The patients were divided by coronary angiography into multi-vessel disease group

double-vessel group and mono-vessel disease group.Result:The ox-LDL levels of the patients in both ACS and non-ACS groups[(185.44±70.11)

(139.51±58.790) mg·L-1] were siginificantly higher than that in normal controls group [(80.47±25.96 mg·L-1]

(P<0.001)

and the ox-LDL level of patients in ACS group was siginificantly higher than that in non-ACS group(P<0.001).Different plasma levels of ox-LDL were found in the multi-vessel

double-vessel and mono-vessel disease group

[(180.34±76.92)

(149.18.15±64.80)

(137.74±58.09) mg·L-1]. The ox-LDL levels in multi-vessel disease group were siginificantly higher than that in mono-vessel group(P<0.01).Multiple linear regression analysis showed that ox-LDL levels siginificantly correlated with the sevesity of coronary artery disease (R2=0.046

β=0.208

P=0.000).Conclusion:Elevated ox-LDL presented in patients with coronary heart disease is correlated with the severity coronary artery lesion

especially in the patients with acute coronary syndrome.