Determination of Dihydroartemisinin from Dihydroartemisinin Soft Capsule by HPLC

ZHAN Li-zhi; ZHAN Ai-qiong; LIN Yan-fang; YANG Zhao-li; YANG Jia-qing; ZHANG Mei-yi

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Determination of Dihydroartemisinin from Dihydroartemisinin Soft Capsule by HPLC

更新时间：2024-01-04

- Determination of Dihydroartemisinin from Dihydroartemisinin Soft Capsule by HPLC
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 19, Pages: 112-114(2012)
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- Published：2012
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ZHAN Li-zhi, ZHAN Ai-qiong, LIN Yan-fang, et al. Determination of Dihydroartemisinin from Dihydroartemisinin Soft Capsule by HPLC[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(19): 112-114.
DOI：

ZHAN Li-zhi, ZHAN Ai-qiong, LIN Yan-fang, et al. Determination of Dihydroartemisinin from Dihydroartemisinin Soft Capsule by HPLC[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(19): 112-114. DOI：

摘要

目的:建立双氢青蒿素软胶囊中双氢青蒿素含量测定的方法。方法:采用DikaDiamonsilC18柱(4.6mm×150mm

5μm);以0.1mol·L-1磷酸二氢钾溶液(pH2.5)-乙腈(65:35)为流动相;流速0.8mL·min-1;检测波长为234nm

柱温18℃。结果:双氢青蒿素在8~40μg·mL-1线性良好

r=0.99992

平均回收率99.6%

RSD0.66%。结论:该法操作简便、快捷、准确;适用于双氢青蒿素软胶囊中双氢青蒿素含量测定。

Abstract

Objective:To establish a method for the assay of dihydroartemisinin from Dihydroartemisinin Soft Capsules. Method:The assay was performed by a Diamonsil C18 columm(4.6 mm×150 mm

5 μm) and a mobile phase of 0.1 mol·L-1 potassium dihydrogen phosphate(pH 2.5)-acetonitrile with radio of 65:35

and the flow rate was 0.8 mL·min-1.The wavelength of detector was set at 234 nm and the column temperature was at 18℃. Result:Dihydroartemisinin has a good linearity in the range of 8-40 μg (r=0.999 92

n=5)

and the average recovery is 99.6% with RSD 0.7%(n=9). Conclusion:The method is simple

rapid and accurate and suitable for the determination of dihydroartemisinin in Dihydroartemisinin Soft Capsules.

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Related Author

LIANG Tingjun

ZHANG Guoxin

LIU Ying

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LIN Na

Zhao CUI

Shuo LI

Hua-jing WANG

Related Institution

School of Pharmacy，Fujian University of Traditional Chinese Medicine

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

Artemisinin Research Centre，China Academy of Chinese Medical Sciences

Jilin Agricultural University

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences

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