Optimization of One-step Granulation Technology for Xinjianwei Package Tablet

ZHENG Yan-chun; YANG Dong-li; CUI Ya-hui; ZHANG Dong-ge; YAN Chun-feng; QIN Ting

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Optimization of One-step Granulation Technology for Xinjianwei Package Tablet

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- Optimization of One-step Granulation Technology for Xinjianwei Package Tablet
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 18, Pages: 62-63(2012)
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- Published：2012
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ZHENG Yan-chun, YANG Dong-li, CUI Ya-hui, et al. Optimization of One-step Granulation Technology for Xinjianwei Package Tablet[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(18): 62-63.
DOI：

ZHENG Yan-chun, YANG Dong-li, CUI Ya-hui, et al. Optimization of One-step Granulation Technology for Xinjianwei Package Tablet[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(18): 62-63. DOI：

摘要

目的: 优选新健胃包芯片一步制粒工艺。方法: 以颗粒软硬度、性状、粒径大小、可压性及片芯中碳酸氢钠含量为考察指标

采用单因素试验对影响制粒的各关键因素进行考察。结果: 新健胃包芯片制粒工艺在不改变原辅料

物料温度45℃

进风温度在50~60℃

5%淀粉浆为黏合剂的条件下

制备的颗粒可压性、流动性均较好

压制的包芯片稳定

且提高了碳酸氢钠含量。结论: 该颗粒采用一步制粒法生产可操作性强

产品质量稳定提高

可为大生产提供技术参考。

Abstract

Objective: To optimize one-step granulation technology for Xinjianwei package tablet. Method: With particle hardness

particle size

compressibility

properties and the content of sodium bicarbonate in tablet core as indexes

single-factors test was used to investigate key factors on granulation technology for Xinjianwei package tablet. Result: Granulation technology of Xinjianwei package tablet didn't change original materials

material temperature was 45℃

inlet air temperature was 50-60℃

5% starch slurry as adhesive

under these conditions

prepared particle had excellent compressibility and mobility

package tablet was stability

and the content of sodium bicarbonate had been raised. Conclusion: One-step granulation had very excellent operability

quality of products was stability and was improved

it could provided reference for mass production.

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Related Author

ZHENG Yan-chun

YANG Dong-li

CUI Ya-hui

ZHANG Dong-ge

YAN Chun-feng

QIN Ting

REN Gang

HE Xiao-ru

Related Institution

Chengde Jingfukang Pharmaceutical Group Co.Ltd,New Excipients of Traditional Chinese MedicineEngineering Research Center of Hebei Province

School of Pharmacy,Nanchang University

Key Laboratory of Modern Preparation of Traditional Chinese Medicine

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