Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 14, Pages: 188-191(2012)
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Published:2012
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ZHU Hu-hu, YU Sup-Tursun, Skandar-Bakeri. Research on Anti-cancer Effect of Xinjiang Jujube[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(14): 188-191.
DOI:
ZHU Hu-hu, YU Sup-Tursun, Skandar-Bakeri. Research on Anti-cancer Effect of Xinjiang Jujube[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(14): 188-191.DOI:
Objective: To study the anti-cancer effection of Xinjiang Jujube. Method: ICR mice were randomly divided into model group
cyclophosphamide(CTX) group
25% jujube juice group
50% jujube juice group
100% jujube juice group
CTX+100% jujube juice group (n=10). Right forelimb axillary subcutaneous inoculation of S180 mouse sarcoma cells 24 h after administration (jujube juice orally 20 mL·kg-1·d-1
CTX intraperitoneal injection of 50 mg·kg-1·d-1) 14 d after the determination of tumor weight inhibition rate
index of thymus and spleen
organs
peripheral blood
serum interleukin-2(IL-2) and tumor necrosis factor-alpha(TNF-α)
the survival time and life prolongation rate. Result: Compared with model group
the CTX group
100% jujube juice group and the CTX+100% jujube juice group tumor weight
thymus
spleen index was significantly reduced; compared with the CTX group
50% jujube juice group
100% jujube juice group and the CTX+100% jujube juice group
thymus
spleen index was significantly increased; compared with model group
White blood cell count(WBC)
platelet count(PLT)
the CTX group decreased significantly
100% jujube juice group
RBC and WBC significantly increased; compared with the CTX group
50%group of jujube juice
jujube juice group of 100% and CTX+100% jujube juice group
WBC and PLT was significantly increased; compared with model group
the CTX group of IL-2 and TNF-α levels decreased significantly; compared with the CTX group.50% jujube juice group
100% jujube juice group and CTX+100% jujube juice group IL-2 and TNF-α significantly increased; compared with model group
50% jujube juice group
100% jujube juice group and CTX+100% jujube juice group significantly prolonged the survival time; compared with the CTX group
CTX+100% jujube juice group significantly prolonged survival time. Conclusion: Xinjiang jujube can significantly inhibit the growth of tumor cells in the mice.
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