Objective: To evaluate the efficacy and safety of tetramethylpyrazine (TMP) combining with mecobalaminein in treatment of diabetic peripheral neuropathy (DPN).[WTHZ]Method: Randomized trial controlled(RCT) on TMP combining mecobalamine in treatment of DPN was retrieved by computer search and manual collection from 1979 to 2011.There were two researchers independently doing a data extraction according to the inclusion criteria of trials and quality assessment about the method of research and the extraction of valid data were then made based on Meta analysis.[WTHZ]Result: In eleven RCTs involving 918 patients who met the standards

Meta-analysis indicated that TMP combining mecobalamine in treatment of DPN was more effective in alleviatingpain or numbness of extremities than mecobalamine medicine alonely[OR=0.29

95%CI(0.21

0.41)

P=0.000]and the conduction velocity between (motor nerve)MNCV and(sensory nerve)SNCV in sensory nerve and pheroneal nerve [MD=4.92

95%CI(4.39

5.45)

P=0.000;MD=5.24

95%CI(4.73

5.75)

P=0.000]。Only one trial reported an adverse reactions occurrence induced by high-dose TMP combining with Methylcobalamin

such as dizziness and headache.[WTHZ]Conclusion: Based on the review

TMP combining with mecobalamine may have positive effect on DPN

but the need more high-quality RCT in order to draw firm conclusions of large randomized

double blind and placebo-controlled trial.