Objective: Explore the therapeutic effect of chronic periodontitis with Zhibai Dihuang pills(ZDP) combined with periocline and its effect on infla mmatory factor in gingival crevicular fluid. Method: Two hundreds and fourteen patients with chronic periodontitis were randomly divided into treatment group and control group

the patients in treatment group injected Periocline into the periodontal pocket until the drug pocket overflow

once a week

and ZDP(3# Tid)

the patients in control group received routine therapy

the therapeutic effect and changes of inflammatory factor were observed after treatment. Result: The total effective rates of the treatment group by 96.3%were higher than that of the control group by 81.5% (P<0.05). The levels of sulcus bleeding index(SBI)

sulcus bleeding index( SBI)

probing depth (PD)

attachment loss (AL)

plaque index(PLI)

interleukin-16(IL-6)

interleukin-8(IL-8)

tumor necrosis factor-α(TNF-α ) had no significant difference between both groups before the treatment

after 4 weeks

the levels of those of both group were reduced significantly(P＜0.05

P<0.01)).SBI

PD

AL

PLI

IL-6

IL-8

TNF-α was lowed in treatment group than those in the control group (P<0.05). Conclusion: The therapeutic effect of Zhibai Dihuang pills combined with periocline in treatment of chronic periodontitis is obvious

which is an effective method to chronic periodontitis.