Objective: To determine the clinical efficacy and safety of Tuibai decoction combined with NB-UVB irradiation in treating vitiligo. Method: One hundred and thirty-seven patients with vitiligo were divided into 3 groups. In treating group with 46 cases

Tuibai decoction was orally given twice a day

200 mL per time

and combined with NB-UVB irradiation twice a week with an initiated dose of 0.5 J·cm-2

and increasing the dose with 10%-20% per time till the erythema appeared with 3 month treating course. In control groupⅠwith 46 cases

only taken tuibai decoction. In control group Ⅱ with 45 cases

only NB-UVB irradiation was applied for 3 month treating course. Result: The efficiency in treatment group

the control groupⅠ

the control group Ⅱwas 73.91%

52.17%

48.89%

respectively. The difference between the treatment group and the two control groups was statistically significant (P<0.05)

and the difference between the control group Ⅰand Ⅱ wa not statistically significant

efficiency of the head and face was remarkably higher than that of the trunk and extremities (P<0.01). The onset time of the treatment group was significantly shorter than that in control groups

and the difference was statistically significant (P<0.01)

but the control group Ⅰcompared with control group

Ⅱ

the difference was not statistically significant. Conclusion: Tuibai decoction combined with NB-UVB irradiation is clinically effective and safe in treating vitligo.