Effect of Zhishi Xiebai Guizhi Tang on Hermorrheology and Oxygen Free Radicals in Hyperlipidemia Rat
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Effect of Zhishi Xiebai Guizhi Tang on Hermorrheology and Oxygen Free Radicals in Hyperlipidemia Rat
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 11, Pages: 170-172(2012)
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Published:2012
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XIA Han-xin, ZHANG Ye. Effect of Zhishi Xiebai Guizhi Tang on Hermorrheology and Oxygen Free Radicals in Hyperlipidemia Rat[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(11): 170-172.
DOI:
XIA Han-xin, ZHANG Ye. Effect of Zhishi Xiebai Guizhi Tang on Hermorrheology and Oxygen Free Radicals in Hyperlipidemia Rat[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(11): 170-172.DOI:
Effect of Zhishi Xiebai Guizhi Tang on Hermorrheology and Oxygen Free Radicals in Hyperlipidemia Rat
Objective: To investigate the effects of Zhishi Xiebai Guizhi Tang on hermorrheology and oxygen free radicala in hyperlipidemia rat. Method: Using hyperlipidemia animal model replicated by hyperlipidemia forage
pravastatin sodium (3.6 mg·kg-1)and different doses of Zhishi Xiebai Guizhi Tang (7.2
3.6
1.8 g·kg-1) were given to rats in model group. Then indexes of hermorrheology
levels of malondialdenhyde(MDA) and superoxide dismutase(SOD) were assayed. Result: Compared with the control group
the whole blood viscosity at the 200 s-1 and 5 s-1 shear rate and plasma viscosity in the model group were increased
the levels of MDA was increased
the level of SOD was decreased obviously. Compared with model group
the level of the whole blood viscosity at the 200 s-1 and 5 s-1 shear rate and plasma viscosity in Zhishi Xiebai Guizhi Tang(high dose) group and the pravastatin sodium group were decreased
the level of MDA was decreased
the level of SOD was increased. Conclusion: The Zhishi Xiebai Guizhi Tang can improve hermorrheology
clean oxygen free radical in rat with hyperlipidemia.
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Related Institution
Chengdu University of TCM
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Research Center for Differentiation and Development of Traditional Chinese Medicine (TCM) Basic Theory/Jiangxi Province Key Laboratory of Biological Etiologies of TCM/First-Level Discipline Platform of Chinese and Western Integrative Medicine/Experimental Animal and Scientific Technology Center of Jiangxi University of Chinese Medicine/School of Pharmacy, Jiangxi University of Chinese Medicine