Objective:To observe the effect of Tiaozhi mixture on hyperlipidemic fatty liver in rats. Method: Wistar rats were divided into normal group

model group

Tiaozhi mixture therapy groups of high

middle and low doses(37.6

18.8

9.4 g·kg-1)

Methionine group(0.625 g·kg-1). In addition to the normal group

the other four groups were established to be hyperlipidemic fatty liver model by feeding with high fat diet for 10 weeks. Then the model group was given normal saline. The treatment groups were given corresponding drugs by ig administration daily for 4 weeks.Four weeks later

blood and hepatic lipid level and pathological changes of the liver were examined. Result:High dose of Tiaozhi mixture could lower the level of TC[(1.53±0.09)vs(3.30±0.49) mmol·L-1

P <0.01]

TG[(1.73±0.09) vs (2.33±0.13) mmol·L-1

P <0.01]

LDL-C[(0.50±0.16) vs (0.81±0.09) mmol·L-1

P <0.01] and reduce fat accumulation in hepatic cell of Wistar rats. Conclusion: Tiaozhi mixture has exact effect on the hyperlipidemia fatty liver in rats.