Objective:To investigate the antidepressant effect of EtoAc extracts of Gastrodia elata(EEG). Method:Male mice were randomly divided into control group

fluoxetine group(20 mg·kg-1)

chlorimipramine group (20 mg·kg-1)and EEG low

high dose groups(0.063

0.126 g·kg-1). Different groups were intragastrically administrated corresponding medicine once per day for seven days. Then tail suspension test and forced swimming test were used to observe immobility time of mice. And open field test were applied to observe autonomic activity of mice. Result:Intragastric administration of EEG significantly reduced immobility time in both forced swimming test(0.126

0.063 g·kg-1) and tail suspension test (0.126 g·kg-1)in mice. However

EEG did not affect the number of autonomic activitt of mice in the open-field test. Conclusion:The EEG shows an antidepressant-like effect in the despair animal models of depression in mice.