Objective: To investigate short-term effect of smoothing the liver and regulating the spleen treatment combined with hyperthermia and intra-arterial infusion chemotherapy for advanced pancreatic cancer. Method: Sixty in-patients with advanced pancreatic cancer meeting the inclusion criteria

were randomly divided into the treatment group with 28 patients(intra-arterial chemotherapy plus intraperitoneal hyperthermia with Sini Decoction) and the control group with 32 patients(intra-arterial chemotherapy alone).Short-term effect

pain score

liver depression and spleen deficiency Syndrome points

spleen deficiency syndrome points

side effects

physical state score were observed. Result: The treatment group CR + PR + SD(85.71%) was higher than that in the control group (71.88%)

P<0.05. The treatment group pain control CR + PR + MR(85.71%)was higher than that in the control group(62.5%)

P<0.05. Liver depression and spleen deficiency syndrome score in the treatment group and the control group was 10.81±4.09 and 15.27±5.67 accordingly

and showed a statistics difference after intervention treatment than before

P<0.05. Conclusion: Clinical benefit of smoothing the liver and regulating the spleen treatment combined hyperthermia and local intra-arterial infusion chemotherapy is higher than simple arterial infusion chemotherapy.