Objective: To observe apoptosis of nonalcoholic fatty liver in rat liver tissue and discuss mechanism of Qutan Huoxue decoction using non-alcoholic fatty liver rat model. Method: Sixty SD male rats were randomly divided into 2 groups:normal control group with 10 rats

which was given normal diet; model group with 50 rats

which was given high fat diet. The model group. After second week

50 rats were divided into model control group

low dose group (Qutan Huoxue decoction 4.5 g·kg-1)

middle dose group (Qutan Huoxue decoction 9 g·kg-1)

high dose group (Qutan Huoxue decoction 13 g·kg-1) and Kaixilai drug group (30 mg·kg-1). Model control group and normal control group were given the same dose of NS. According to above drug plan

at the end of 8

9

10th week

1-2 rats were dissected from the model group to observe pathological changes in liver tissue and blood biochemical parameters alanine aminotransferase(ALT)

aspartate aminotransferase(AST)

triglycerides(TG)

total cholesterol(TC) and so on. All rats were dissected at the end of 10th week to observe hepatic function

blood lipid and apoptosis. Result: In model control group compared with normal control group

serum ALT

AST

TC

TG level

range of hepatic pathological inflammation

index in hepatic apoptosis showed significantly increased (P<0.01); low

middle

high dose treatment groups of Qutan Huoxue decoction

Kaixilai treatment group compared with model group

their indexes were significantly decreased (P<0.05). Conclusion: Qutan Huoxue decoction can significantly reduce NAFL liver fatty degeneration

regulate lipid metabolism

improve liver function and decrease the apoptosis in liver.