Comparison of Analgesic Efficacy and Effective Fractions of Wild and Cultivated

SHEN Fang; MA Yin-hai; YANG Li-jiang; LU Bin; YUAN Lin

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Comparison of Analgesic Efficacy and Effective Fractions of Wild and Cultivated

更新时间：2024-09-23

- Comparison of Analgesic Efficacy and Effective Fractions of Wild and Cultivated
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 18, Pages: 240-243(2012)
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- Published：2012
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SHEN Fang, MA Yin-hai, YANG Li-jiang, et al. Comparison of Analgesic Efficacy and Effective Fractions of Wild and Cultivated [J]. Chinese journal of experimental traditional medical formulae, 2012, 18(18): 240-243.
DOI：

SHEN Fang, MA Yin-hai, YANG Li-jiang, et al. Comparison of Analgesic Efficacy and Effective Fractions of Wild and Cultivated [J]. Chinese journal of experimental traditional medical formulae, 2012, 18(18): 240-243. DOI：

摘要

目的: 比较野生和栽培金铁锁的镇痛效果及其具镇痛活性的有效部位。方法: 提取分离获得野生和栽培金铁锁根部不同极性的化合物

运用醋酸扭体法和热板法研究其对小鼠疼痛的抑制效果。结果: 无论是野生还是栽培的金铁锁

其浸膏的镇痛效果相似

均含有高活性的镇痛成分。从化学刺激致痛的抑制效果来看

栽培与野生金铁锁活性成分均存在于正丁醇(扭体抑制率分别为99.1%±3.0%和100.0%±0.0%)、乙酸乙酯(97.9%±6.3%和81.9%±11.7%)和石油醚部分(78.8%±17.7%和70.9%±10.3%)

但栽培金铁锁乙酸乙酯部分的镇痛效果(97.9%±6.3%)明显优于野生金铁锁(81.9%±11.7%

P<0.05)。从热刺激致痛模型的镇痛作用来看

野生金铁锁的活性部位为正丁醇部分(30 min痛阈提高率为166.5%±71.6%

60 min为186.9%±79.0%)

栽培金铁锁的活性部位为正丁醇部分(30 min痛阈提高率为128.3%±53.1%

60 min为136.5±65.2%)和乙酸乙酯部分(30 min为53.7%±24.4%

60 min为186.9%±79.0%)。结论: 虽然人工栽培金铁锁的镇痛活性成分与野生药材有所不同

但其镇痛功效与野生药材无明显区别

可作为镇痛药物等效替代野生药材。

Abstract

Objective: To compare the analgesic effect and effective fractions of wild and cultivated Psammosilene tunicoides. Method: compounds of different polarity from roots of wild and cultivated P. tunicoides were extracted

hot plate test and acetic acid writhing test were used in mice for evaluating analgesic effect of the extracts. Result: The extracts of wild and cultivated P. tunicoides produced the similar analgesic effect;both of them contained highly active analgesic ingredients. For the inhibitory effect of the extracts on chemical stimulation induced pain

the active ingredients of wild and cultivated P. tunicoides were found in the parts of n-butanol

ethyl acetate and petroleum. But the ethyl acetate part of artificial cultivation sample had a significant analgesic activity better than that of the wild sample (P<0.05). For the analgesic effect on thermal stimulation induced pain model

the effective fractions of wild P. tunicoides was the n-butanol part

the n-butanol and ethyl acetate parts were in cultivation sample. Conclusion: The artificial cultivation and wild herbs of P. tunicoides

haas the different active ingredients of analgesic function

but their analgesic efficacy do not show a significant difference. So the cultivated P. tunicoides could be used as the equivalent analgesic medicine to substitute the wild herbs.

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Related Author

SHEN Fang1

MA Yin-hai2

YANG Li-jiang1

LU Bin1

YUAN Lin2

SUN Qiyue

LI Shuran

GAO Shuangrong

Related Institution

Chemical Science and Technology Department,Kunming University

Department of Life Science and Technology,Kunming University

Heilongjiang Ji Ren Pharmaceutical Co. Ltd.

Biosafety Laboratory，Institute of Chinese Materia Medica， China Academy of Chinese Medical Sciences

Institute of Chinese Materia Medica， China Academy of Chinese Medicine Sciences

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