Progress on Decreasing Toxicity and Increasing Efficacy Through Compatibility of Aconitine Root Species

WANG Xing; SUN Wei; ZHANG Tie-jun

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Progress on Decreasing Toxicity and Increasing Efficacy Through Compatibility of Aconitine Root Species

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- Progress on Decreasing Toxicity and Increasing Efficacy Through Compatibility of Aconitine Root Species
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 18, Pages: 327-331(2012)
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- Published：2012
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WANG Xing, SUN Wei, ZHANG Tie-jun. Progress on Decreasing Toxicity and Increasing Efficacy Through Compatibility of Aconitine Root Species[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(18): 327-331.
DOI：

WANG Xing, SUN Wei, ZHANG Tie-jun. Progress on Decreasing Toxicity and Increasing Efficacy Through Compatibility of Aconitine Root Species[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(18): 327-331. DOI：

摘要

总结近年来川乌、附子常用药对在临床应用、化学研究、药理毒理研究等方面所取得的进展

为临床安全有效应用乌头类中药提供理论依据。通过阅读大量近几年川乌、附子常用药对的文献报道

对其进行总结概述。川乌和附子通过合理配伍

可达到减毒增效的作用

扩大其应用范围。目前的川乌、附子配伍减毒研究已取得了一定进展

但研究还不够深入

需要进一步研究配伍减毒增效作用的机制

为临床应用提供科学依据。

Abstract

To summarize the research process of universal herbal pair containing aconitine in recent years

including clinical application

chemical research

pharmacological and toxicological research

apply theoretical bases of the aconite root species safely and effectively used in clinical application. Literatures on universal herbal pair containing aconitine in recent years were summarized and analyzed. Suitable compatibility of Aconitine root species can decrease toxicity and increase efficacy

enlarge applied range. There are some advancements in studies on reducing the toxicity and increasing efficacy of aconitine by using compatibility at present

but many researches are superficial

so it is necessary for us to further study the mechanism of detoxification and synergism by using compatibility

in order to apply theoretical bases of clinical application.

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Related Author

WANG Xing1

SUN Wei2

ZHANG Tie-jun2

CHEN Yaman

CUI Jinpeng

ZHANG Juan

LIU Qingpu

GONG Haiyan

Related Institution

Tianjin University of Traditional Chinese Medicine

Tianjin Institute of Pharmaceutical Research

College of Agronomy， Henan Agricultural University

Henan Provincial Engineering Technology Research Center for Quality Control and Evaluation of Traditional Chinese Medicine， Henan University of Chinese Medicine

Beijing University of Chinese Medicine

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