Objective: To observe the anti-hypertentive and sedative effects of Tianma Gouteng Jiangya capsules (TGJC). Method: Spontaneous hypertention rats were orally given TGJC (5.4

10.8

21.6 g·kg-1) daily for 4 weeks. Anti-hypertentive effect was evaluated. Mice were orally given TGJC (7.8

15.6

31.2 g·kg-1) daily for 5 days. One hour after the last administration

intraperitoneal injection of sodium pentobarbital 55 mg·kg-1 was carried out

and sleep time was recorded. Similarly

intraperitoneal injection of thio-semicarbazide (16 mg·kg-1) was carried out

the time of convulsions and the incubation period were recorded. In addition

one hour after the last administration

mice were placed in YLS-1A versatile recorder to record the number of locomotor activities in mice within 10 min. Result: Three doses of TGJC could significantly reduce the blood pressure in the hypertensive rats (P<0.01). TGJC high dose could significantly prolong the sodium pentobarbital induced sleep time P<0.05)

extend the thio-semicarbazide-induced seizure latency (P<0.05)

without significant effect on the number of seizures. TGJC had no effect on locomotor activity in mice. Conclusion: TGJC has some anti-hypertention and sedative effects.