Protective Effect of Ersheng Decoction on Myocardial Ischemia Induced by Isoproterenol in Rats
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Protective Effect of Ersheng Decoction on Myocardial Ischemia Induced by Isoproterenol in Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 13, Pages: 204-208(2012)
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Published:2012
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ZHOU Li-ya, LI Xin. Protective Effect of Ersheng Decoction on Myocardial Ischemia Induced by Isoproterenol in Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(13): 204-208.
DOI:
ZHOU Li-ya, LI Xin. Protective Effect of Ersheng Decoction on Myocardial Ischemia Induced by Isoproterenol in Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(13): 204-208.DOI:
Protective Effect of Ersheng Decoction on Myocardial Ischemia Induced by Isoproterenol in Rats
Objective: The effect of Ersheng decoction on myocardial ischemia in rats. Method: Wistar rats was randomly divided into 5 groups
Ersheng decoction high dose group
middle dose group
low dose group(100
50
20 g·kg-1)
control group and model group
ten rats in each group. The changes of electrocadiograph (ECG) II lead
serum level of thromboxane A2(TXA2)
prostacylin(PGI2) and the content of Bax mRNA
Bcl-2 mRAN on myocardial cells were detected. Result: Compared with model control group
Ersheng decoction group decreased the T wave(P<0.05)
and could reduce the blood serum content of TXA2
which was significantly lower in Ersheng decoction high dose group (102.16±9.41)μg·L-1 than that in model group(188.81±38.70)μg·L-1 (P<0.05)
increase the serum PGI2 content
which was significantly higher in Ersheng decoction high dose group (112.10±10.45)μg·L-1 than that in model group(36.10±4.26) μg·L-1 (P<0.05); Ersheng decoction could inhibit Bax mRNA expression
up-regulation of Bcl-2 mRNA expression(P<0.05). Conclusion: Ersheng decoction can protect myocardial cells against myocardial ischemia injury
which may be related to regulating expression of Bcl-2 mRNA and Bax mRNA.