Effects of Didang Decoction on Expression of Intercellular Adhesion Molecular-1 in Diabetic Nephropathy Rats
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Effects of Didang Decoction on Expression of Intercellular Adhesion Molecular-1 in Diabetic Nephropathy Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 12, Pages: 143-145(2012)
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Published:2012
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GAO Ruo-yu, QU Zhu-qiu, CHANG Bai. Effects of Didang Decoction on Expression of Intercellular Adhesion Molecular-1 in Diabetic Nephropathy Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(12): 143-145.
DOI:
GAO Ruo-yu, QU Zhu-qiu, CHANG Bai. Effects of Didang Decoction on Expression of Intercellular Adhesion Molecular-1 in Diabetic Nephropathy Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(12): 143-145.DOI:
Effects of Didang Decoction on Expression of Intercellular Adhesion Molecular-1 in Diabetic Nephropathy Rats
Objective: To investigate influence of Didang decoction on the low extremity vascular disease of STZ-induced diabetic rats. Method: After being injected streptozotocin (STZ) into the caudal vein and fed with the high fat diet
diabetes model rats were divided into normal control group
model control group
Didang decoction group
and the rosiglitazone group. After continuous stomach perfusion administration for 12 weeks
the change of blood glucose
total urinary protein in 24 h
serum creatinine were detected with correlative methods
and the expression of intercellular adhesion molecule-1(ICAM-1) in kidney were examined by inmunohistochemical technique. Result: Compared with normal control group
the expression of ICAM-1 in model control group is significantly increased.Compared with model control group
the expression of ICAM-1 is decreased in Didang decoction group
and rosiglitazone group. Conclusion: Didang decoction can restrain expressions of ICAM-1 on kidney
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