Determination of Rhubarb Anthraquinones in  Tablets by QAMS and External Standard Method

ZHANG Kai-bing; FENG Wei-hong; WANG Zhi-min; ZHANG Qi-wei; LI Xia; YANG Fei; LI Dong-ying; JI Li-na

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Determination of Rhubarb Anthraquinones in Tablets by QAMS and External Standard Method

更新时间：2024-01-04

- Determination of Rhubarb Anthraquinones in Tablets by QAMS and External Standard Method
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 11, Pages: 61-65(2012)
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- Published：2012
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ZHANG Kai-bing, FENG Wei-hong, WANG Zhi-min, et al. Determination of Rhubarb Anthraquinones in Tablets by QAMS and External Standard Method[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(11): 61-65.
DOI：

ZHANG Kai-bing, FENG Wei-hong, WANG Zhi-min, et al. Determination of Rhubarb Anthraquinones in Tablets by QAMS and External Standard Method[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(11): 61-65. DOI：

摘要

目的: 采用"一测多评"法与外标法测定新清宁片中4种大黄蒽醌类成分的含量

并对测定结果进行比较。方法: 采用RP-HPLC

Accurasil C18色谱柱(4.6 mm×250 mm

5 μm)

流动相甲醇-0.4%磷酸水溶液(85 :15)

流速1 mL·min-1

柱温30 ℃

检测波长254 nm。结果: 20批新清宁片中4种蒽醌类成分QAMS计算值与ESM实测值无显著性差异

RSD<5%。结论: 在一定色谱条件下

QAMS确定的相对校正因子可作为常数用于含大黄制剂的质量评价。

Abstract

Objective: To determine the contents of four kinds of anthraquinone components in Xinqingning tablet by quantitative analysis of multi-component with a single-marker(QAMS) and external standard method(ESM) respectively

and compare results by this two methods. Method: RP-HPLC determination was performed at 30 ℃ with Accurasil C18 column (4.6 mm×250 mm

5 μm)

mobile phase of methanol-0.4% phosphoric acid (85 : 15)

detection wavelength at 254 nm

and flow rate of 1.0 mL·min-1. Result: There was no significant difference between calculated value of QAMS and measured value of ESM for four kinds of anthraquinone components from Xinqingning tablet

RSD<5%. Conclusion: Under certain chromatographic conditions

relative correlation factor could be used as a constant for quality evaluation of Rheum palmatum preparation which was determined by QAMS.

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