Objective: To investigate the effects of Qingkailing and Puerarin injection on blood pressure in conscious dogs. Method: The sensor was implanted in abdomen of conscious dogs. Qingkailing and Puerarin injection were intravenously injected after the dogs recovered. The change of blood pressure in dogs was monitored with Dataquest A.R.T.4.3 system. Result: After the administration of Compound 48/80 and Tween-80

blood pressure of dogs was decreased

which was statistically significant.Changes of blood pressure in dogs were not apparent after the administration of Qingkailing injection of 1.2

2.3

11.5 mL·kg-1 or Puerarin injection of 0.24 mL·kg-1.Blood pressure in dogs was decreased after the administration of Puerarin injection of 0.47 mL·kg-1.Average blood pressure dropped from (115.35±7.73) mmHg to (91.74 ±10.18) mmHg(P<0.01) and systolic blood pressure dropped from (147.33±14.65) mmHg to (112.88 ±6.51) mmHg(P<0.01) thirty minutes later. Conclusion: Qingkailing injection has no effect on blood pressure in conscious dogs

the reduction of blood pressure in dogs caused by Puerarin injection is related to dosage

which may be caused by the pharmacological actions of itself.We preliminary conclude that Qingkailing injection and Puerarin injection cannot cause anaphylactoid reaction in conscious Beagle dogs.