Comparison of Clarification Technology for Xiao'er Qingre Zhike Oral Solution

WANG Ling; ZHOU Zhi-chuan; GAO Xiao-li

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Comparison of Clarification Technology for Xiao'er Qingre Zhike Oral Solution

更新时间：2024-01-04

- Comparison of Clarification Technology for Xiao'er Qingre Zhike Oral Solution
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 10, Pages: 55-59(2012)
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- Published：2012
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WANG Ling, ZHOU Zhi-chuan, GAO Xiao-li. Comparison of Clarification Technology for Xiao'er Qingre Zhike Oral Solution[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(10): 55-59.
DOI：

WANG Ling, ZHOU Zhi-chuan, GAO Xiao-li. Comparison of Clarification Technology for Xiao'er Qingre Zhike Oral Solution[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(10): 55-59. DOI：

摘要

目的: 优选小儿清热止咳口服液的澄清工艺。方法: 比较高速离心法、乙醇沉淀法、ZTC1+1Ⅲ型天然澄清剂法3种澄清工艺对小儿清热止咳口服液中收膏率、麻黄碱和黄芩苷相对含量的影响。结果: 乙醇沉淀法为最佳澄清工艺

其工艺条件为药液浓度比1∶1

加95%乙醇调至含醇量60%

冷藏放置6 h。结论: 优选的澄清工艺稳定

可行。

Abstract

Objective: To optimize clarification technology of Xiao'er Qingre Zhike oral solution. Method: To compare effect of three clarification technology(high-speed centrifugation method

ethanol precipitation method and ZTC1+1Ⅲadsorption clarify agent method) on yield of extract and relative content of ephedrine and baicalin which were active components in Xiao'er Qingre Zhike oral solution. Result: The best clarification technology was ethanol precipitation method

its technology conditions were:the concentration ratio of sample liquid 1∶1 with adding 95% ethanol to adjust ethanol concentration to 60%

refrigerated 6 h. Conclusion: Optimized clarification technology for Xiao'er Qingre Zhike oral solution was stable and feasible.

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Related Author

ZHOU Zhi-chuan2

GAO Xiao-li1

WANG Ling1

CHEN Zhen-gui

ZHANG Ni-yu

OU Jin-xiu

XIE An

Zhou Fang

Related Institution

College of Pharmacy,Xinjiang Medical University,Urmuqi

Department of Pharmacy, First Affiliated Hospital of Xinjiang Medical University,Urmuqi

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