The Effect of 3 Kinds of Formulas with Different Therapeutic Methods on Hemorheology and ET-1 Level in Rats with Type 2 Diabetes Insulin Resistance
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The Effect of 3 Kinds of Formulas with Different Therapeutic Methods on Hemorheology and ET-1 Level in Rats with Type 2 Diabetes Insulin Resistance
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 9, Pages: 247-250(2012)
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Published:2012
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ZHANG Ye, XIE Ming, LIU Yue. The Effect of 3 Kinds of Formulas with Different Therapeutic Methods on Hemorheology and ET-1 Level in Rats with Type 2 Diabetes Insulin Resistance[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(9): 247-250.
DOI:
ZHANG Ye, XIE Ming, LIU Yue. The Effect of 3 Kinds of Formulas with Different Therapeutic Methods on Hemorheology and ET-1 Level in Rats with Type 2 Diabetes Insulin Resistance[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(9): 247-250.DOI:
The Effect of 3 Kinds of Formulas with Different Therapeutic Methods on Hemorheology and ET-1 Level in Rats with Type 2 Diabetes Insulin Resistance
Objective: To investigate the effects of 3 kinds of formulas with different therapeutic methods on hemorheology and endothelin-1 (ET-1) level in rats with type 2 diabetes mellitus(T2DM). Method: The rat model was established by feeding of high glucose and fat diet with peritoneal injection of (STZ). Different formulas were given to the modeling rats. Then indexes of
hemorheology and levels of ET-1 were tested. Result: Compared with the model group
the level of the whole blood viscosity at the 200 s-1
5 s-1 shear rate and plasma viscosity of theⅠformula (Yiqi Yangyin Huatan Huoxue fang) group and the Ⅲ formula (Huatan Jiangzhuo Huoxue Huayu fang) group were decreased obviously
the level of ET-1 of all formulas was decreased obviously. Conclusion: The effect of Ⅰformula (Yiqi Yangyin Huatan Huoxue fang) is the best among the 3 kinds of formulas.The Yiqi Yangyin Huatan Huoxue fang has an improvement effect on hemorheology and endothelial cell injury in rats with type 2 diabetes mellitus.