Optimization of Extraction and Purification Process for Pingxiao Granule by Orthogonal Test
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Optimization of Extraction and Purification Process for Pingxiao Granule by Orthogonal Test
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 18, Pages: 42-45(2012)
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Published:2012
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ZHANG Chao, PAN Jin-huo, SHI Suo-fang, et al. Optimization of Extraction and Purification Process for Pingxiao Granule by Orthogonal Test[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(18): 42-45.
DOI:
ZHANG Chao, PAN Jin-huo, SHI Suo-fang, et al. Optimization of Extraction and Purification Process for Pingxiao Granule by Orthogonal Test[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(18): 42-45.DOI:
Optimization of Extraction and Purification Process for Pingxiao Granule by Orthogonal Test
Objective: To optimize water extraction and alcohol precipitation technology for Pingxiao granule. Method: With solid ratio
total extraction rate of ephedrine hydrochloride and paeoniflorin as comprehensive evaluation indexes
orthogonal test was used to optimize extraction technology with soaking time
the amount of water
decocting times and decocting time as factors;With total transfer rate of ephedrine hydrochloride and paeoniflorin as index
effect of solid-liquid ratio
alcohol precipitation time and the concentration of ethanol on alcohol precipitation technology was optimized by orthogonal test. Result: Optimum water extraction process was as follows:decocted 3 times with 8 times the amount water
1 h each time;Optimum alcohol precipitation process was:the concentration of decoction liquid concentrated 2 g · mL-1
precipitated to the concentration of ethanol 60%
stirred well
stilled 8 h. Conclusion: These optimized technology could ensure effective components saved to the maximum
Optimization of Extraction and Purification Process for Pingxiao Granule by Orthogonal Test
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Optimization of Extraction Technology for Zhichan Decoction by Orthogonal Test
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Related Author
ZHANG Chao
PAN Jin-huo
SHI Suo-fang
YAN Guo-jun
SHI Qian-ping
YANG Xiu-juan
HONG Yan-long
WU Fei
Related Institution
College of Pharmacy,Nanjing University of Chinese Medicine
上海中医药大学中药现代制剂技术教育部工程研究中心
Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine
Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences