Objective: Observation of Danshen injection combined with irbesartan hydrochlorothiazide in the treatment of refractory hypertension patients. Method: With a case in sixty patients with refractory hypertension were randomly divided into the observation group and the control group

30 cases in each group. Two groups of patients were prescribed diet

the control group treated with irbesartan and hydrochlorothiazide tablets

1 time/d

1 pill/time. In the observation group with irbesartan and hydrochlorothiazide tablets on the basis of Salvia miltiorrhiza injection 20 mL+200 mL intravenous saline infusion

1 times/d. The 2 groups were treated for 2 weeks with 1 courses of treatment

after 2 courses of treatment efficacy. Result: Significant efficiency was observed in group 76.67%

control group 53.33%

two groups had significant difference (P<0.05). The total efficiency of the observation group 93.33%

control group 73.33%

two groups had significant difference (P<0.05). Two groups of systolic blood pressure(SBP)

diastolic blood pressure(DBP) after treatment were significantly decreased (P<0.05)

the observation group is better than control group (P<0.05). The two groups after treatment

serum cystation C(Cys C)

serum creatinine(SCr)

urea nitrogen(BUN) and urinary mALB were significantly improved (P<0.05)

the observation group is better than control group (P<0.05). The two group is China should occur rate showed no significant difference. Conclusion: The effect of Danshen injection combined with irbesartan hydrochlorothiazide in the treatment of refractory hypertension clinical curative effect is remarkable

the antihypertensive effect of good

and can have good serum Cys C

mALB

SCr

BUN in urine.