Effect of the Different Extracts from  on Isolated Ileum Smooth Muscle in Guinea Pig

LIU Hong-yan; GUO Jian-sheng; WANG Xiao-juan; CHEN Jun; ZHANG Meng; NIE Zi-wen

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Effect of the Different Extracts from on Isolated Ileum Smooth Muscle in Guinea Pig

更新时间：2024-01-04

- Effect of the Different Extracts from on Isolated Ileum Smooth Muscle in Guinea Pig
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 17, Pages: 175-178(2012)
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- Published：2012
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LIU Hong-yan, GUO Jian-sheng, WANG Xiao-juan, et al. Effect of the Different Extracts from on Isolated Ileum Smooth Muscle in Guinea Pig[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(17): 175-178.
DOI：

LIU Hong-yan, GUO Jian-sheng, WANG Xiao-juan, et al. Effect of the Different Extracts from on Isolated Ileum Smooth Muscle in Guinea Pig[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(17): 175-178. DOI：

摘要

目的: 观察檀香不同萃取物对豚鼠离体回肠平滑肌收缩的影响

探讨其作用机制。方法: 利用BL-420F生物机能实验系统

在HW-400S恒温平滑肌浴槽中

37 ℃下观察檀香不同萃取物对豚鼠离体回肠运动功能的影响。结果: 檀香水提液乙醚萃取物、檀香水提液乙酸乙酯萃取物、檀香醇提液乙醚萃取物、檀香醇提液乙酸乙酯萃取物对豚鼠离体肠自主运动有抑制作用(P<0.01)

表现为振幅减低;檀香水提液乙醚萃取物、檀香水提液乙酸乙酯萃取物、檀香醇提液石油醚萃取物、檀香醇提液乙醚萃取物、檀香醇提液乙酸乙酯萃取物对乙酰胆碱(Ach)造成的豚鼠离体肠痉挛状态有拮抗作用(P<0.01)

表现为振幅减低;檀香水提液乙酸乙酯萃取物对阿托品造成的松弛状态有明显的协同作用(P<0.01)

表现为振幅减低。结论: 檀香不同萃取物对豚鼠离体肠平滑肌有抑制作用。

Abstract

Objective: To observe different extracts from Santalum album on isolated smooth muscle contraction. Method: Using BL-420F biological function experimental system and the HW-400S constant temperature smooth muscle bath isolated smooth muscle contraction was observed. Result: Water extraction liquid ethyl ether extract of S. album

water extraction liquid ethyl acetate extract of S. album

ethanol-extraction liquid ethyl ether extract of S. album

ethanol-extraction liquid ethyl acetate extract of S. album had inhibitory effect (P<0.01).Water extraction liquid ethyl ether extract of S. album

water extraction liquid ethyl acetate extract of S. album

ethanol-extraction liquid petroleum ether extract of S. album

ethanol-extraction liquid ethyl ether extract of S. album

ethanol-extraction liquid ethyl acetate extract of S. album from had a antagonist function (P<0.01). Water extraction liquid ethyl acetate extract of S. album

have obvious synergy on the flabby condition caused by atropine (P<0.01). Conclusion: Different extracts of S. album possess the inhibition on isolated intestinal smooth muscle.

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