Objective: To optimize vacuum extraction process parameters of Carthamus tinctorius. Method: With transfer rate and dry extract ratio of hydroxysafflor yellow A as indexes

orthogonal test was used to investigate the amount of water

degree of vacuum

extraction time

extaction times and other factors

and compared with document method and ordinary pressure boiling method. Result: Optimized vacuum extraction process was:adding 12 times the amount of water to extract 3 times with 20 min each time

vacuity was -0.045--0.055 MPa.Optimized method was better than document method and ordinary pressure boiling method. Conclusion: Optimized process was stable and feasible.