Objective: To study the antilipemic effect of banana peel polyphenols in hyperlipidemic rats. Method: Sixty healthy male SD rats were randomly divided into six groups: normal control group (NC)

model control group (MC)

positive control group (PC

simvastatin group)

low dose group of banana peel polyphenols (P1)

middle dose group of banana peel polyphenols(P2)

high dose group of banana peel polyphenols(P3). The rats in the normal control group were fed with normal diet

and the MC groups were given high fat diet; the PC groups were given high fat diet

and given orally administrated with simvastatin at dose of 10 mg·kg-1

semel in die; the P1

P2

P3

groups were given high fat diet

and orally administrated with banana peel polyphenol (30

60

120 mg·kg-1)

semel in die. After 40 days rats were sacrificed and blood sample was collected to evaluate serum total cholesterol (TC)

serum triglyceride (TG)

low-density lipoprotein cholesterol (LDL-C)

high density lipoprotein cholesterol (HDL-C). Result: Compared with the NC group

the level of TG(1.14±0.21) mmol·L-1

TC(3.06±0.24)mmol·L-1

LDL-C(2.97±0.12)mmol·L-1 in MC group was increased for

and HDL-C(0.89±0.11)mmol·L-1 level was decreased in rats fed high fat diet(P<0.05)

and then the levels of TC

TG and LDL-C in the treatment groups were decreased

and HDL-C levels were increased(P<0.05). Conclusion: It demonstrates that the banana peel polyphenols could effectivly reduce the levels of blood lipid in hyperlipidemic rats.