Study on Spectrum-effect Relationship betweent Fingerprint of Essential Oil and of Anti-tumor Effect from
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Study on Spectrum-effect Relationship betweent Fingerprint of Essential Oil and of Anti-tumor Effect from
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 13, Pages: 91-94(2012)
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Published:2012
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ZENG Jian-hong, MO Xuan-yong, DAI Ping, et al. Study on Spectrum-effect Relationship betweent Fingerprint of Essential Oil and of Anti-tumor Effect from [J]. Chinese journal of experimental traditional medical formulae, 2012, 18(13): 91-94.
DOI:
ZENG Jian-hong, MO Xuan-yong, DAI Ping, et al. Study on Spectrum-effect Relationship betweent Fingerprint of Essential Oil and of Anti-tumor Effect from [J]. Chinese journal of experimental traditional medical formulae, 2012, 18(13): 91-94.DOI:
Study on Spectrum-effect Relationship betweent Fingerprint of Essential Oil and of Anti-tumor Effect from
Objective: To investigate the effective component group represented by fingerprint contributed to pharmacodynamic by grey relational analysis
and provide a reference for traditional Chinese medicine quality control and develop evaluation criteria of pharmacodynamics. Method: The fingerprint of essential oil from Curcuma kwangsiensis was established by gas chromatography-mass spectrometry (GC-MS)
and the anti-tumor effect of curcuma oil was studied. At the premise of the acquired GC-MS characteristic of fingerprint and pharmacodynamic data to inhibiting proliferation of nasopharyngeal carcinoma cell
the relational grade and relational sequence between fingerprint of essential oil and of inhibiting proliferation rate were calculated by grey relational analysis. Result: According to the relational grade the sequence of contribution to inhibiting proliferation to nasopharyngeal carcinoma cell was curcumol>curdione>β-elemene>germacrone>curzerenone>α-caryophyllene>δ-selinene>β-caryophyllene>β-elemenone>a-pinene>α-caryophyllene>eucalyptol>camphor>2-nonanol>isoborneol>curzerene>δ-elemene>camphene>D-limonene>borneol. Conclusion: The anti-tumor effect of C. kwangsiensis is the result of combined effect of 'effective component group. This study identifies the effective component group represented by fingerprint contributed to pharmacodynamic
and provides a reference for establishing fingerprint of traditional Chinese medicine's spectrum-effect relationship
traditional Chinese medicine quality control and develop evaluation criteria of pharmacodynamics.
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Related Institution
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