Objective: To observe the protective effect of Fufang Danshenfang and total saponin of Dioscorea compatibility on myocardial ischemia reperfusion injury in rats. Method: Seventy SD rats were randomly divided into 10 groups: sham-operation group

model group

Salvia extract (300 mg·kg-1)

total saponins of panax notoginseng (PNS) 100 mg·kg-1

dioscorea saponins 100 mg·kg-1

compatibility (Salvia extract+PNS+borneol+Dioscorea saponins) three dose of (300+100+10+50)

(300+100+10+100)

(300+100+10+200) mg·kg-1

compound Danshen tablets 300 mg·kg-1

Tongxinluo capsules 300 mg·kg-1. Each group was ig administrted for 7 consecutive days.The model of myocardial ischemia reperfusion injury in rats was induced by ligation of the left anterior descending of the coronary artery(LAD) after one hour of end administration. Serum superoxide dismutase (SOD)

lactic clehydrogense(LDH) and creatine kinase isoenzyme(CK-MB) activity were determined by kit

the TTC staining method was used to determine the myocardial infarct size

TUNEL staining was used to detect apoptosis. Result: Compatibility (300+100+10+100) mg·kg-1 could significantly enhance SOD activity (P<0.01) significantly reduce myocardial LDH and CK-MB activity (P<0.01); compared with the ingredients and the original side

infarct size of 20.78% was significantly lower than the Salvia extract 34.04%(P<0.05)

PNS 34.62% (P<0.05)

the total saponin of Dioscorea 36.19% (P<0.05)

Fufang Danshen Tablets 26.47%; apoptosis rate of 16.53%

25.08% (P<0.05) was significantly lower than the Salvia extract 25.08%

PNS 22.12% (P<0.05)

the total saponin of Dioscorea 24.45% (P<0.05)

Fufang Danshen Tablets 18.14%. Conclusion: Fufang Danshenfang and the total saponin of Dioscorea compatibility have showed protective effects on myocardial ischemia reperfusion injury

which is much better than other compostion and Fufang Danshenfang.