Progress in New Preparations of Podophyllotoxin and its Derivatives for Anti-tumor Effect
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Progress in New Preparations of Podophyllotoxin and its Derivatives for Anti-tumor Effect
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 13, Pages: 296-299(2012)
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Published:2012
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HUANG Xiong, LIN Min-chao, YU Bai-chun, et al. Progress in New Preparations of Podophyllotoxin and its Derivatives for Anti-tumor Effect[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(13): 296-299.
DOI:
HUANG Xiong, LIN Min-chao, YU Bai-chun, et al. Progress in New Preparations of Podophyllotoxin and its Derivatives for Anti-tumor Effect[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(13): 296-299.DOI:
Progress in New Preparations of Podophyllotoxin and its Derivatives for Anti-tumor Effect
the research of novel dosage form of podophyllotoxin and its derivatives is opening up a broader prospect. Relevant literatures are collected
compiled for review. The applications of podophyllotoxin in liposome nanoparticles
layered double hydroxide
drug-loaded polymer micelles
and other new drug carrier system and its anti-tumor effect were introduced. The podophyllotoxin derivatives etoposide microspheres
oral microemulsion
nano-liposomes
β-cyclodextrin and other new formulations for anti-cancer in targeted therapy
increasing the solubility of hydrophobic drugs
sustained-release effect of the drug were also introduced. Further studies on podophyllotoxin and its derivatives as novel targeted agents will reduce toxicity and enhance the characteristics of anti-tumor effect. All these could serve as referential basis for the reasonable development of podophyllotoxin and its derivatives with new formulations.