Objective: To investigate the effect of Yiqi Yangyin Huazhuo Tongluo recipe (YQYYHZTLr) on plasma connective tissue growth factor (CTGF)

type IV collagen and Cystatin C(Cys C) in patients with early diabetic nephropathy (DN). Method: Six-three patients with DN were randomly divided into the control group(n=31) and the treatment group (n=32). The control group was applied DN regular treatment and the treatment group was added to YQYYHZTLr on the basis of regular treatment. Both of them were treated for two months. Plasma CTGF and type IV collagen were determined with ELISA in two groups both before and after treatment. Plasma Cys C was determined with particle-enhanced turbidimetric immunoassay (PETIA). Fasting blood glucose and urinary albumin excretion rate (UAER) were also examined. Result: Plasma levels of CTGF and type IV collagen between the two groups were significantly lower than those of pretreatment (P＜0.05

P＜0.01)

and favorable changes of levels of other parameters (Cys C

UAER and fasting blood glucose) were also demonstrated (P＜0.05

P＜0.01). At the same time

plasma levels of CTGF

type IV collagen and Cys C were different significantly in the treatment group after treatment compared with the control group(P＜0.05

P＜0.01). Conclusion: YQYYHZTLr could delay the development of early DN by decreasing the levels of CTGF and type IV collagen.