Objective: To study the effect and pharmacological mechanism of Renshen Baihu decoction in non-insulin-dependent diabetes mellitus (NIDDM) rats. Method: The rats were bred with high lipid special food for 4 weeks

then intraperitoneal injected streptozotocin (STZ) to establish the NIDDM animal model. After that

the rats were administrated with Renshen Baihu decoction (15

7.5

3.7 g·kg-1

respectively) or metformin

respectively. Model group and control group animal were administrated with tap water. 4 weeks later

observed the contents of blood glucose

blood lipid and insulin

glucose and insulin tolerance to analyze the influence of Renshen Baihu decoction on NIDDM animal model. Result: Renshen Baihu decoction obviously decreased the amount of blood glucose(P<0.05 or P<0.01)

triglyceride(P<0.05 or P<0.01)

and cholesterol(P<0.05 or P<0.01)

increased the amount of high-density lipoproteins(P<0.05)

improved glucose and insulin tolerance(P<0.05 or P<0.01)

reinforced the sensitivity of rat to exogenous insulin(P<0.05 or P<0.01)

but showed less effect on the content of insulin. Conclusion: Renshen Baihu decoction had significant effect to decrease blood glucose

triglyceride and cholesterol

improved glucose tolerance

reinforced the sensitivity to exogenous insulin. Its hypoglycemic effect maybe due to it strengthened the sensitivity of insulin of the animal.