Study on Correlation of Plasma Concentration before and after Ultrafine Grinding and Analgesic Effect of Corydalis Decumbentis Rhizoma

HUANG Yi-ke; ZHANG Shui-han; FENG Xiao-yan; LIU Cai-ying

您当前的位置：

首页 >

文章列表页 >

Study on Correlation of Plasma Concentration before and after Ultrafine Grinding and Analgesic Effect of Corydalis Decumbentis Rhizoma

更新时间：2024-01-04

- Study on Correlation of Plasma Concentration before and after Ultrafine Grinding and Analgesic Effect of Corydalis Decumbentis Rhizoma
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 17, Pages: 231-234(2012)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2012
- 稿件说明：
移动端阅览
HUANG Yi-ke, ZHANG Shui-han, FENG Xiao-yan, et al. Study on Correlation of Plasma Concentration before and after Ultrafine Grinding and Analgesic Effect of Corydalis Decumbentis Rhizoma[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(17): 231-234.
DOI：

HUANG Yi-ke, ZHANG Shui-han, FENG Xiao-yan, et al. Study on Correlation of Plasma Concentration before and after Ultrafine Grinding and Analgesic Effect of Corydalis Decumbentis Rhizoma[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(17): 231-234. DOI：

摘要

目的: 考察夏天无饮片超微粉碎前后对小鼠口服生物利用度的影响。方法: 样品为夏天无超微饮片和普通饮片各1 g·mL-1

以10 mL·kg-1ig给药

1次/天

共7 d

研究醋酸所致小鼠扭体反应的镇痛作用及血液中所含生物碱量的相关性。结果: 夏天无超微粉碎后

对醋酸所致小鼠扭体反应的抑制作用强于普通饮片(P<0.05)

超微粉组镇痛作用强于普通饮片约4%

同时血液中生物碱的含量高于普通饮片约5%。结论: 夏天无超微粉碎后提高了生物利用度。

Abstract

Objective: To study the correlation of plasma concentration before and after ultrafine grinding and Corydalis Decumbentis Rhizoma bioavailability by oral administration in mice. Method: Acetic acid induced writhing response was used to observe analgesic effect in mice and the blood contained in the amount of alkaloids. Result: By ultrafine grinding of Corydalis Decumbentis Rhizoma

stronger inhibitory effect on acetic acid induced writhing response was fund compared with the ordinary pieces

alkaloid content in the blood was higher than ordinary pieces. Conclusion: Ultrafine grinding can improve the bioavailability of Corydalis Decumbentis Rhizoma.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Structure-activity Omics of Anti-inflammatory and Analgesic Effect of Corydalis Rhizoma in Qizhi Weitong Granules

Application of Natural Ingredients of Traditional Chinese Medicine in Pain Management： A Review

Chemical Constituents from Stems of Zanthoxylum bungeanum

Rapid Analysis and Identification of Chemical Constituents from Siwei Tumuxiang San by HPLC-Q-Exactive-MS/MS

Suspension Culture and Alkaloid Content of Pinelliae Rhizoma Tuber Under Stimulation of Salicylic Acid

Related Author

QIN Xinpeng

ZOU Wei

MENG Ying

LIU Sicong

ZHENG Ying

BAO Yongrui

WANG Shuai

LI Tianjiao

Related Institution

China Resources Sanjiu Medical & Pharmaceutical Co. Ltd.

The Second People's Hospital of Dalian

Liaoning Province Modern TCM Research and Engineering Laboratory

Liaoning Multi-dimensional Analysis of TCM Technical Innovation Center

College of Pharmacy， Liaoning University of Traditional Chinese Medicine （TCM）

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰