Study on Effective Part of Anti-hyperuricemia in Gardeniae Fructus

ZHU Ji-xiao; ZENG Jin-xiang; LUO Guang-ming; ZHU Yu-ye; WANG Xiao-yun; WU Bo; SHI Jing-jing; XU Yun-feng

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Study on Effective Part of Anti-hyperuricemia in Gardeniae Fructus

更新时间：2024-01-04

- Study on Effective Part of Anti-hyperuricemia in Gardeniae Fructus
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 14, Pages: 159-161(2012)
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- Published：2012
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ZHU Ji-xiao, ZENG Jin-xiang, LUO Guang-ming, et al. Study on Effective Part of Anti-hyperuricemia in Gardeniae Fructus[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(14): 159-161.
DOI：

ZHU Ji-xiao, ZENG Jin-xiang, LUO Guang-ming, et al. Study on Effective Part of Anti-hyperuricemia in Gardeniae Fructus[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(14): 159-161. DOI：

摘要

目的: 确定栀子降尿酸作用有效部位。方法: 用系统溶剂法提取分离得到4个部位

分别为石油醚部位、乙酸乙酯部位、正丁醇部位和水液部位

采用氧嗪酸钾盐诱导的小鼠急性高尿酸血症模型

研究栀子总提物和4个部位对高尿酸血症小鼠血清尿酸水平和肝脏黄嘌呤氧化酶的影响。结果: 栀子总提物组、乙酸乙酯组和水组具有较好的降尿酸作用

栀子总提物组、石油醚组和水组能够较好的抑制黄嘌呤氧化酶的活性。栀子总提取物和各部位提取物对正常小鼠血清尿酸水平没有显著影响。结论: 栀子乙酸乙酯提取部位和水液部位为降尿酸活性部位

其降尿酸作用部分机制是通过抑制黄嘌呤氧化酶的活性。

Abstract

Objective: To determine the effective part of anti-hyperuricemia in Gardeniae Fructus. Method: Four fractions were obtained by systematic solvent extraction

petrol ether extract

ethyl acetate extract

butanol extract and water-soluble part.Total extract of Gardenia Fructus (TEG) and its different extracts were administrated to hyperuricemia mice induced by potassium oxonate

then the level of uric acid and xanthine oxidase in hyperuricemia mice were observed. Result: TEG

ethyl acetate extract and water-soluble part could obviously reduce the level of serum uric acid in hyperuricemia mice

TEG

petrol ether extract and water-soluble part could obviously inhibit the activity of and xanthine oxidase in the liver. TEG and its different extracts had no effect on the level of serum uric acid in normal mice. Conclusion: Ethyl acetate extract and water-soluble part from Gardeniae Fructus are the active fraction for anti-hyperuricemia

and the effect is related to its inhibition of xanthine oxidase.

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