Study on Rationality for Compatibility of Kushen Injection

ZHANG Zhi-wei; HAI Li-na; GAO Zhi-yuan; WANG Jin-hua

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Study on Rationality for Compatibility of Kushen Injection

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- Study on Rationality for Compatibility of Kushen Injection
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 9, Pages: 229-232(2012)
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- Published：2012
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ZHANG Zhi-wei, HAI Li-na, GAO Zhi-yuan, et al. Study on Rationality for Compatibility of Kushen Injection[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(9): 229-232.
DOI：

ZHANG Zhi-wei, HAI Li-na, GAO Zhi-yuan, et al. Study on Rationality for Compatibility of Kushen Injection[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(9): 229-232. DOI：

摘要

目的: 探讨苦参与白土苓配伍的合理性。方法: 采用小鼠体内抑瘤、镇痛、止血、抗炎四种模型

比较复方苦参注射液(含生药15

7.5

3.75 g·kg-1)、苦参注射液(含生药10.5

5.25

2.63 g·kg-1)、白土苓注射液(含生药4.5

2.25

1.13 g·kg-1)与药效的关系。结果: 复方苦参注射液、苦参注射液具有明显的体内抑瘤(高、中剂量)、镇痛(高、中剂量)、抗炎(高剂量)作用和止血作用(高剂量);白土苓注射液仅有一定的镇痛(高、中剂量)、缩短凝血时间(高剂量)作用;苦参与白土苓配伍为复方苦参注射液后

可增强苦参的抑瘤作用(高、中、低剂量)

可提高苦参的镇痛作用强度和作用时间

缩短凝血时间(高剂量)和出血时间(高剂量)

并提高苦参的抗炎作用(高、中、低剂量)。结论: 苦参和白土苓配伍应用具有协同增效作用

表明复方苦参注射液配伍应用具有合理性。

Abstract

Objective: To study the rationality for compatibility of Kushen and Baituling. Method: Four mouse models of tumor

pain

hemorrhage and inflammation were used to evaluate the pharmacodynamic effects of Compound Kushen injection (15.75

3.75 g·kg-1)

Kushen injection (10.5

5.25

2.63 g·kg-1)and Baituling injection (4.5

2.25

1.13 g·kg-1). Result : Compound Kushen injection and Kushen injection showed significant anti-tumor effect (high and middle doses)

analgesia (high and middle doses)

anti-inflammation (high dose)and hemostasis (high dose) effects. Baituling injection showed effects on analgesia (high and middle doses) and hemostasis (high dose). Compound Kushen injection could enhance the anti-tumor effect and anti-inflammation (three doses) of Kushen

promote the action of analgesia for strengthen and duration

shorten the coagulation time and hemorrhage time (high dose). Conclusion : Kushen and Baituling have synergistic action with compatible rationality in Compound Kushen injection.

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Related Author

ZHANG Zhi-wei1

HAI Li-na1

GAO Zhi-yuan1

WANG Jin-hua1

SUN Qiyue

LI Shuran

GAO Shuangrong

GUO Shanshan

Related Institution

Beijing Zhendong Guangming Drug Research Institute

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences

Biosafety Laboratory，Institute of Chinese Materia Medica， China Academy of Chinese Medical Sciences

Heilongjiang Ji Ren Pharmaceutical Co. Ltd.

Institute of Chinese Materia Medica， China Academy of Chinese Medicine Sciences

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