Effect of Dongyao Wuwei Zhixie Decoction on Serum Levels of IL-1 and IL-10 in Rats with Ulcerative Colitis
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Effect of Dongyao Wuwei Zhixie Decoction on Serum Levels of IL-1 and IL-10 in Rats with Ulcerative Colitis
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 17, Pages: 227-230(2012)
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Published:2012
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LAI Xiang-quan, HE Ben-qiu, ZHOU Hong-yan, et al. Effect of Dongyao Wuwei Zhixie Decoction on Serum Levels of IL-1 and IL-10 in Rats with Ulcerative Colitis[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(17): 227-230.
DOI:
LAI Xiang-quan, HE Ben-qiu, ZHOU Hong-yan, et al. Effect of Dongyao Wuwei Zhixie Decoction on Serum Levels of IL-1 and IL-10 in Rats with Ulcerative Colitis[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(17): 227-230.DOI:
Effect of Dongyao Wuwei Zhixie Decoction on Serum Levels of IL-1 and IL-10 in Rats with Ulcerative Colitis
Objective: To study the effect of Dongyao Wuwei Zhixie decoction on serum levels of interleukin-1(IL-1)and interleukin-10(IL-10) in rats with intestinal ulcerative colitis and. Method: Ulcerative colitis rat model was copied by 2
4
6-TNBS. Sixty SD rats were randomly divided into normal group
model group
Dongyao Wuwei Zhixie decoction low
middle and high dose group(5.5
11
22 g·kg-1)
Mesalazie group (0.5 g·kg-1)
10 in each group. The general situation and histopathological changes were observed.The ultrastructural changes of UC model rats were investigated by transmission electron microscope and the rat serum levels of IL-1
IL-10 were detected by ELISA 10 days later. Result: Dongyao Wuwei Zhixie decoction effectively improved the serum levels of IL-10
reduced the serum levels of IL-1
and had significant effect of repairing the intestinal mucosal injury. Conclusion: Dongyao Wuwei Zhixie decoction achieves a therapeutic effect by inhibiting the production of proinflammatory cytokines IL-1 and improving the production of antiinflammatory cytokines IL-10.
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