Effect of Erzi Capsule on Apoptosis Genes in Rat with Spermatogenic Failure

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Effect of Erzi Capsule on Apoptosis Genes in Rat with Spermatogenic Failure

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- Effect of Erzi Capsule on Apoptosis Genes in Rat with Spermatogenic Failure
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 18, Pages: 226-228(2012)
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- Published：2012
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LI Hui. Effect of Erzi Capsule on Apoptosis Genes in Rat with Spermatogenic Failure[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(18): 226-228.
DOI：

LI Hui. Effect of Erzi Capsule on Apoptosis Genes in Rat with Spermatogenic Failure[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(18): 226-228. DOI：

摘要

目的: 观察二紫胶囊对生精障碍大鼠凋亡调控基因的影响。方法: 将40只健康雄性大鼠分为模型组、对照组、二紫胶囊高、低剂量组

以环磷酰胺注射液40 mg ·kg-1

ip制造大鼠生精障碍模型

分别ig生理盐水、二紫胶囊浸膏(4.8

2.4 g ·kg-1)

连续60 d

用TUNEL法检测大鼠睾丸生精细胞凋亡

免疫组化法测定Bax和Bcl-2蛋白在大鼠睾丸组织中的表达。结果: 与模型组相比较

二紫胶囊高、低剂量组生精细胞凋亡指数明显下调

Bax蛋白表达明显下调 (P<0.01)

Bcl-2蛋白表达明显上调 (P<0.01)。结论: 二紫胶囊能通过下调Bax和上调Bcl-2表达

减少生精细胞凋亡的发生。

Abstract

Objective: To investigate effects of Erzi Capsule (EZC) on apoptosis genes in rats with spermatogenic failure and to explore the related mechanism of action for treatment of male infertility. Method: Forty male rats were randomly divided in to 4 groups:model group

control group and two EZC dose groups (4.8

2.4 g · kg-1). The rat model of spermatogenic failure was established by intraperitoneal injection of cyclophosphamide (40 mg · kg-1). The treatments were lasted for 60 days. TUNEL method was used to determine apoptosis in spermatogenic cells. Bax and Bcl-2 expressions in testis were tested by immunohistochemical method. Result: Compared with the model group

two doses of EZC group decreased apoptosis index

lowered Bax expression and increased Bcl-2 expression significantly(P<0.01). Conclusion: EZC could downregulate the expression of Bax and upregulation Bcl-2 expression

reduce the incidence of apoptosis in spermatogenic cells.

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Related Institution

Henan Provincial Hospital of Traditinoal Chinese Medicine

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