Evaluation ofRelease and Percutaneous Absorption for Guanxin Gel Ointment

DU Mao-bo; WU Zhi-cheng; LIU Shu-zhi; LI Man-ling; KANG Chen; CHANG Lin

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Evaluation ofRelease and Percutaneous Absorption for Guanxin Gel Ointment

更新时间：2024-01-04

- Evaluation ofRelease and Percutaneous Absorption for Guanxin Gel Ointment
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 11, Pages: 43-45(2012)
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- Published：2012
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DU Mao-bo, WU Zhi-cheng, LIU Shu-zhi, et al. Evaluation ofRelease and Percutaneous Absorption for Guanxin Gel Ointment[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(11): 43-45.
DOI：

DU Mao-bo, WU Zhi-cheng, LIU Shu-zhi, et al. Evaluation ofRelease and Percutaneous Absorption for Guanxin Gel Ointment[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(11): 43-45. DOI：

摘要

目的: 评价冠心凝胶膏剂体外释放和透皮吸收行为。方法: 采用改良Franz扩散池法

以离体小鼠皮肤为屏障进行试验

HPLC测定丹酚酸B含量

考察冠心凝胶膏剂体外透皮吸收行为。结果: 24 h内丹酚酸B累积释药率为92.7%

丹酚酸B累积透过率为21.97%

透过速率为71.90 μg·cm-2·h。结论: 冠心凝胶膏剂体外释放和透皮行为均满足中药凝胶膏剂的体外释放和透皮规律。

Abstract

Objective: To evaluate in vitro release and transdermal absorption behavior of Guanxin gel ointment. Method: The content of salvianolic acid B was determined by HPLC

modified Franz diffusion cell method was applied to investigate in vitro transdermal absorption behavior of Guanxin gel ointment with isolated mouse skin as barrier. Result: In 24 hours

accumulative release rate of salvianolic acid B was 92.7%

accumulated transdermal rate of salvianolic acid B was 21.97%

transmission rate was 71.9 μg·cm-2·h. Conclusion: In vitro release and transdermal behavior of Guanxin gel ointment were all satisfied with the law of in vitro release and transdermal of Chinese medicine gel ointment.

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Related Institution

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Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

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