Express of B7-1 and B7-2 in Peripheral Blood from Rats with Collagen-Induced Arthritis Treated by Scorpio-Scolopendra
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Express of B7-1 and B7-2 in Peripheral Blood from Rats with Collagen-Induced Arthritis Treated by Scorpio-Scolopendra
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 14, Pages: 151-154(2012)
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Published:2012
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HUANG Xiao-ying, ZHAO Hai-mei, ZUO Zhi-qin, et al. Express of B7-1 and B7-2 in Peripheral Blood from Rats with Collagen-Induced Arthritis Treated by Scorpio-Scolopendra[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(14): 151-154.
DOI:
HUANG Xiao-ying, ZHAO Hai-mei, ZUO Zhi-qin, et al. Express of B7-1 and B7-2 in Peripheral Blood from Rats with Collagen-Induced Arthritis Treated by Scorpio-Scolopendra[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(14): 151-154.DOI:
Express of B7-1 and B7-2 in Peripheral Blood from Rats with Collagen-Induced Arthritis Treated by Scorpio-Scolopendra
Objective: To observe express of B7-1(CD80) and B7-2(CD86) in peripheral blood from rats with collagen-induced arthritis (CIA) treated by Scorpio-Scolopendra. Method: Sixty female Wistar rats were randomly divided into 6 groups
the normal control group
the model control group
the low-dose
the middle-dose and the high-dose Scorpio-Scolopendra group(1∶1)
and the type Ⅱcollagen group. Rat arthritis model was induced by injection of collagen. The number of CD80+ and CD86+cell in peripheral blood was tested by flow cytometry. Result: Compared with the model groups
the level of CD80+ cell(55.7±6.31)% was decreased obviously in the middle and low dose of Scorpio-Scolopendra groups (46.6±6.34
30.8±15.14)%(P<0.05). While the level of the CD80+CD86- cell (43.7±10.26)%in peripheral blood from rats in the model groups was higher than in the low dose of Scorpio and Scolopendra group(25.3±12.67)% (P<0.05). Conclusion: The mechanism of Scorpio and Scolopendra treated RA is likely to down-regulate express of B7-1(CD80) and B7-2 (CD86) in peripheral blood.