Exploration of Dosage of Toxic Herb Based on Dosage Convert of Classical Prescription——Ameliorative Effect of Sini Decoction with Different Dosages on Blood Pressure, Heart Rate, Respiration in Bloodletting Hypotension Rats

WANG Jue; HAN Jing-dan; MA Da-yong; FANG Ji-ping

您当前的位置：

首页 >

文章列表页 >

Exploration of Dosage of Toxic Herb Based on Dosage Convert of Classical Prescription——Ameliorative Effect of Sini Decoction with Different Dosages on Blood Pressure, Heart Rate, Respiration in Bloodletting Hypotension Rats

更新时间：2024-01-04

- Exploration of Dosage of Toxic Herb Based on Dosage Convert of Classical Prescription——Ameliorative Effect of Sini Decoction with Different Dosages on Blood Pressure, Heart Rate, Respiration in Bloodletting Hypotension Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 13, Pages: 181-184(2012)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2012
- 稿件说明：
移动端阅览
WANG Jue, HAN Jing-dan, MA Da-yong, et al. Exploration of Dosage of Toxic Herb Based on Dosage Convert of Classical Prescription——Ameliorative Effect of Sini Decoction with Different Dosages on Blood Pressure, Heart Rate, Respiration in Bloodletting Hypotension Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(13): 181-184.
DOI：

WANG Jue, HAN Jing-dan, MA Da-yong, et al. Exploration of Dosage of Toxic Herb Based on Dosage Convert of Classical Prescription——Ameliorative Effect of Sini Decoction with Different Dosages on Blood Pressure, Heart Rate, Respiration in Bloodletting Hypotension Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(13): 181-184. DOI：

摘要

目的: 选取四逆汤(Sini decoction

SND)为代表

采用目前较公认的经方剂量折算标准"1两=3 g"、"1两=6.69 g"以及"1两=13.92 g"

同时配伍附子用量折合15 g

30 g

60 g的变化

通过动物实验研究

比较不同折算标准的药效及安全性。方法: 复制大鼠失血性低血压模型

分成四逆汤高、中、低折算剂量组和模型组

以多道生理信号采集系统记录全程血压、呼吸、心电时间曲线变化

观察四逆汤不同折算剂量对大鼠血压、心电、呼吸等重要生命体征的改善作用。结果: 模型组大鼠收缩压、舒张压、平均动脉压明显下降

心率、呼吸减慢;SND低剂量组大鼠收缩压升高(P<0.01)、心率增快(P<0.05)、呼吸加快(P<0.05)

SND中剂量组大鼠收缩压升高(P<0 01)、心率增快(P<0.05)

SND高剂量组心率增快(P<0.05)。SND各剂量组舒张压、平均动脉压与模型组比较无显著性差异。结论: SND在一定剂量下对失血性低血压大鼠具有明显的升压、强心、促进呼吸的作用。随着SND各组分剂量的逐渐增加

上述药效作用未见明显增强

甚至在高剂量使用时表现出一定的副作用。提示在临床运用SND时若增大各组分剂量

应对其可能出现的毒副作用予以重视。

Abstract

Objective: To compare the pharmacologic effects of Sini decoction with dosages of different convertsion criteria. Method: Forty male Wistar rats were randomly divided into four groups: blood-letting hypotension group (control group)

Sini decoction low

middle and high dosage groups(SND-L group

SND-M group and SND-H group). The model of hypotension was replicated by blood-letting. The curves of blood pressure (BP)

heart rate (HR)

respiratory (R) were recorded during experiment by physiological polygram. At the end of the experiment the changes of curves were analyzed. Result: To be compared with control group

mean systolic pressure(MSP)

respiratory frequency(RF) were increased significantly in SND-L group. MSP and HR were increased significantly in SND-M group. HR was increased significantly in SND-H group. There was no significant difference among groups in mean diastolic pressure (MDP) and mean arterial pressure (MAP). Conclusion: Sini decoction with proper dosage could elevate BP

strengthen heart and promote respiratory function in blood-letting hypotension rats

protect and maintain the function of vital organs. However

no enhanced effects obviously appeaved as the dosage increased. side-effect were noted when high dosage (especially Aconiti Lateralis Radix Preparata) was used. These results suggest that we should pay more attention to the possible risk when increasing the dosage of Sini decoction in clinical practice.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Comparative Study of Zengye Decoction and Sini Decoction in Inhibiting Ventricular Remodeling

The Influence of Sini Decoction on Contracting Function of Isolated Toad Heart

Effect of Sini Decoction on Learning and Memory Ability in Rats with Vascular Dementia

Based on CaN-NFAT3 Signalling Pathways to Explore the Molecular Mechanism of Sini Decoction in Treatments of Heart Failure

Related Author

LV Jian

GU Wei-liang

DU Jun

CHEN Chang-xun

WANG Ying

NING Kang-jian1

Zhang Yong-hu1

Related Institution

Hunan University of traditional Chinese medicine

Jiangxi University of Traditional Chinese Medicine

National Pharmaceutical Engineering Center

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰