Vasodilative Action of Combinations of Hypotensive Components of Traditional Chinese Medicines on Rat Isolated Thoracic Aorta
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Vasodilative Action of Combinations of Hypotensive Components of Traditional Chinese Medicines on Rat Isolated Thoracic Aorta
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 14, Pages: 147-151(2012)
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Published:2012
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XU Ji-yang, ZHANG Ying-qiao, BIAN Xiao-hong, et al. Vasodilative Action of Combinations of Hypotensive Components of Traditional Chinese Medicines on Rat Isolated Thoracic Aorta[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(14): 147-151.
DOI:
XU Ji-yang, ZHANG Ying-qiao, BIAN Xiao-hong, et al. Vasodilative Action of Combinations of Hypotensive Components of Traditional Chinese Medicines on Rat Isolated Thoracic Aorta[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(14): 147-151.DOI:
Vasodilative Action of Combinations of Hypotensive Components of Traditional Chinese Medicines on Rat Isolated Thoracic Aorta
Objective: To investigate the vasodilative action of gastrodin
baicalin
tetramethylpyrazine
puerarin and their combinations on rat thoracic aorta
and to select the best combination of hypotensive components. Method: The rat thoracic aorta was taken as specimen and the vasodilative action of single components and their combinations on rat thoracic aorta which was pre-constricted with NE was tested. Result: Gastrodin
baicalin
tetramethylpyrazine and puerarin exerted a dose-dependent vasodilative action on rat isolated thoracic aorta rings. The results of orthogonal optimization experiment showed that the best combination including gastrodin (0.64 g·L-1)
baicalin (0.12 g·L-1)
tetramethylpyrazine (0.32 g·L-1) and puerarin (0.64 g·L-1) presented more obvious contraction than any single component. And the vasodilatation rate was 89.37%. Conclusion: The above components and their combination have vasodilative action on the NE pre-constricted rat thoracic aorta
but the effect of latter is stronger than the former.
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