Objective: To study the immunoregulation of the ethanol extracts from fruits of Acanthopanax gracilistylus in immunosuppressive mice. Method: The mice were randomly divided into the fruits of A. gracilistylus high dose group

middle dose group

low dose group(2.8

1.4

0.7 g·kg-1)

positive control group

control group and model control group. Each group was administrated intragastrically at 20 mL·kg-1 for 10 days(n=10). The control group and model control group were administrated intragastrically with the same dose of distilled water. From the 7th day

except the control group

other groups were injected cyclophosphamide(80 mg·kg-1)intraperitoneally to produce the immunosuppressive mice model for 4 days. The weight of immune organs and the carbonic particle clearance methods were used to evaluate the effects of the ethanol extracts on non-specific immune function in immunosuppressive mice by spleen index

thymus index

carbonic particle clearance index and corrected phagocytic index; the serum hemolysin examination was used to evaluate the effects of ethanol extracts by serum hemolysin index. Result: The ethanol extracts had no significant impacts on spleen index and thymus in immunosuppressive mice

but could improve carbonic particle clearance index

corrected phagocytic index and serum hemolysin index of immunosuppressive mice(P<0.05 or P<0.01). Conclusion: The ethanol extracts of the fruits of A. gracilistylus can enhance non-specific immune function and specific humoral immune function in immunosuppressive mice.