Study on the Anti-inflammation Effects and Mechanism by Tetra-acetylated Puerarin
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Study on the Anti-inflammation Effects and Mechanism by Tetra-acetylated Puerarin
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 13, Pages: 177-180(2012)
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Published:2012
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LI Heng-hua, CHEN Guo-qing, Zhang Yi, et al. Study on the Anti-inflammation Effects and Mechanism by Tetra-acetylated Puerarin[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(13): 177-180.
DOI:
LI Heng-hua, CHEN Guo-qing, Zhang Yi, et al. Study on the Anti-inflammation Effects and Mechanism by Tetra-acetylated Puerarin[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(13): 177-180.DOI:
Study on the Anti-inflammation Effects and Mechanism by Tetra-acetylated Puerarin
Objective: To study the anti-inflammation effects of tetra-acetylated puerarin and its mechanism. Method: Male rats were randomly divided into normal control group
model group
tetra-acetylated puerarin high
middle and low dose (80
40
20 mg·kg-1)group
and indomethacin(5 mg·kg-1)group. Tetra-acetylated puerarin was given by injection for 4 days
and the model was established at 30 min after last injection.To abserve the influence of tetra-acetylated puerarin on acute paw oedema induced by carrageenin
content of prostaglandin E2(PGE2) in inflammatory tissue
as well as tumor necrosis factor-α(TNF-α) and interleukin-1β(IL-1β) in serum was measured. Result: Tetra-acetylated puerarin(80 mg·kg-1) showed marked suppressive effect on paw oedema induced by carrageenin in rats(P<0.01). In addition
the content of PGE2(P<0.05)in infl-ammatiory tissue along with the content of TNF-α(P<0.05) and IL-1β(P<0.05)in serum was all was reduced at the dosage of 80 mg·kg-1. Conclusion: Tetra-acetylated puerarin has a marked suppressive effect on paw oedema induced by carrageenin in rats.Its effects may be related to the inhibition on inflammatory factors.
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Related Institution
Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences/PUMC
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Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine (TCM)
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