Percutaneous Enhancement Function of Volatile Oil from  on Ligustrazine Phospate Patch

LUO Hong-mei; MA Yun-shu; HUANG Jin-e; ZHANG Gui-hua; KANG Shao-jian

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Percutaneous Enhancement Function of Volatile Oil from on Ligustrazine Phospate Patch

更新时间：2024-01-04

- Percutaneous Enhancement Function of Volatile Oil from on Ligustrazine Phospate Patch
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 11, Pages: 40-43(2012)
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- Published：2012
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LUO Hong-mei, MA Yun-shu, HUANG Jin-e, et al. Percutaneous Enhancement Function of Volatile Oil from on Ligustrazine Phospate Patch[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(11): 40-43.
DOI：

LUO Hong-mei, MA Yun-shu, HUANG Jin-e, et al. Percutaneous Enhancement Function of Volatile Oil from on Ligustrazine Phospate Patch[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(11): 40-43. DOI：

摘要

目的: 考察不同质量分数的丁香挥发油对磷酸川芎嗪贴剂的经皮促渗作用。方法: 用改良Franz扩散池法

以氮酮为阳性对照

不含促渗剂的磷酸川芎嗪贴剂为阴性对照

考察含3%

10%的丁香挥发油对模型药磷酸川芎嗪经小鼠皮肤的促渗效果

采用HPLC测定磷酸川芎嗪的含量。结果: 4种质量分数的丁香油对磷酸川芎嗪12 h平均累积渗透量(Q12)分别为3.030

4.066

1.845

1.205 mg·cm-2;其12 h时增渗倍数分别为1.54

2.06

0.96

0.62。与阴性对照组的Q12比较

5%丁香油与3%丁香油促渗作用显著。结论: 3%

5%的丁香油能明显提高磷酸川芎嗪在贴剂中的渗透量

且促渗效果好。

Abstract

Objective: To investigate percutaneous penetration effect of different concentration of volatile oil from Eugenia caryophyllata on ligustrazine phosphate (LP). Method: Modified Franz diffusion cell method was used

with azone as positive control

LP without penetration enhancers as negative control

penetration effect of 3%

7% and 10% volatile oil from E. caryophyllata on LP through mouse skin were investigated

the content of LP was determined by HPLC. Result: Average cumulative permeation volume(Q12)of the 4 concentrations of volatile oil from E. caryophyllata on LP in 12 h were 3.030

4.066

1.845 and 1.205 mg·cm-2

respectively;and enhancing rates (ER) in 12 h were 1.54

2.06

0.96 and 0.62

respectively.Compared with Q12 of negative control group

5% and 3% volatile oil from E. caryophyllata had significantly enhancing effect. Conclusion: 3% and 5% volatile oil from E. caryophyllata could enhance permeation volume of LP through mouse skin obviously

and had great enhancing effect.

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Related Institution

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

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Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences

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