Effect of Dahuang Zhechong Pill on Myocardial Fibrosis Induced by Isoprenaline in Rats
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Effect of Dahuang Zhechong Pill on Myocardial Fibrosis Induced by Isoprenaline in Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 13, Pages: 169-172(2012)
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Published:2012
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SONG Jin-yan, LIU Jun-tian, PANG Xiao-ming, et al. Effect of Dahuang Zhechong Pill on Myocardial Fibrosis Induced by Isoprenaline in Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(13): 169-172.
DOI:
SONG Jin-yan, LIU Jun-tian, PANG Xiao-ming, et al. Effect of Dahuang Zhechong Pill on Myocardial Fibrosis Induced by Isoprenaline in Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(13): 169-172.DOI:
Effect of Dahuang Zhechong Pill on Myocardial Fibrosis Induced by Isoprenaline in Rats
Objective: To study the protective effects of Dahuang Zhechong Pill (DHZCP) on myocardial fibrosis induced by isoprenaline (Iso) in rats. Method: Fifty SD rats were divided into 5 groups randomly: normal control
model control
positive control (Danshen
1 g·kg-1·d-1)
low and high doses of DHZCP (1.6
3.2 g·kg-1·d-1). Myocardial fibrosis model was established by subcutaneous injection of 5 mg·kg-1Iso in rats for 10 days except normal control rats. The drugs were administered intragastrally to rats for 28 days. The histopathological change was examined
and level of hydroxyproline and malondialdehyde (MDA) as well as superoxide dismutase (SOD) activity were determined in the myocardial tissue. Result: The results showed that heart index
level of hydroxyproline and MDA
collagen volume fraction (CVF)
perivascular collagen area (PVCA) were increased
and SOD activity was reduced in myocardial tissue of model rats in comparison with normal rats. The histopathological examination showed that there was a significant collogen proliferation and myocardial fibrosis. However
DHZCP improved and reversed the changes induced by Iso. Conclusion: DHZCP is able to reverse the myocardial fibrosis induced by Iso and to improve ventricular remodeling in rats